Matchup
You are stronger late game — farm safe and avoid early trades.
Build vs Seraphine
Build adapted to this matchup
Starting items
Core build
Standard
Summoner spells
61%
32%Anti AD
Anti CC
Anti Tank
DPS
Other options
Domination
Electrocute
Cheap Shot
Grisly Mementos
Relentless Hunter
Sorcery
Axiom Arcanist
Absolute Focus
Power Spikes
Strength by game phase
Annie
SeraphineSeraphine's abilities
Passive, spells and ultimate
Every third basic spell will cast twice from Seraphine. Additionally, casting spells near allies grants her bonus magic damage and range on her next basic attack.
Cooldowns
Cooldowns by spell rank
| Level | Q | W | E | R |
|---|---|---|---|---|
| 3 | 8s | 22s | 11s | – |
| 6 | 7s | 22s | 11s | 2m40 |
| 9 | 6s | 22s | 11s | 2m40 |
| 11 | 6s | 22s | 11s | 2m20 |
| 16 | 6s | 22s | 10s | 2m |
| 18 | 6s | 22s | 9s | 2m |
Playing against Seraphine
How to counter and exploit weaknesses
Spread out to avoid the R chaining — if an ally is hit, move away from them.
Her E alone only slows: it's dangerous ONLY if you're already slowed or CC'd.
Seraphine is immobile and squishy — assassins and flanks punish her well.
Her passive doubles every 3rd ability: if she has the visible halo, prepare for a double cast.
Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026