Aphelios vs Varus

With Gravitum as your main weapon, hit your target to slow them, then cast Weapon Abilities (Q): the cannon roots every enemy it has slowed.

Switch to the right weapon with Phase (W) before Moonlight Vigil (R): you then attack each champion hit with your main weapon, and its effect applies.

Before an objective, check Weapon Queue System (E): it shows the weapon Alune will give you next, and an empty weapon goes to the back of the queue.

Back off after taking a few autos: each one applies a Blight stack from Blighted Quiver (W), and his spells detonate them for damage based on your max health.

If you can engage, go in while he charges Piercing Arrow (Q): charging slows him, and he has no dash to escape.

Get out of the Hail of Arrows (E) zone fast: the desecrated ground slows you and reduces the healing you receive.

When an ally is caught by Chain of Corruption (R), move away from them fast: the corruption spreads to nearby champions, but dies out if you get far enough in time.