Gwen vs Locke

Land 4 autos before Snip Snip! (Q): each auto adds a snip, on top of the first and the last.

Land the center of Snip Snip! (Q): in the center, part of the damage becomes true damage and each snip applies A Thousand Cuts (passive).

Place Hallowed Mist (W) against poke and ranged CC: enemies outside the mist can't target you, except towers.

Cast all three Needlework (R) activations within 6 seconds: the first throws one needle, then three, then five, with growing damage.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.