Kayle vs Locke

Play safe early on: Divine Ascent (passive) empowers your autos with each level, adding range, speed and waves of fire.

Save Celestial Blessing (W) to escape a gank or hold your lane: it heals you and an ally, and gives you both move speed.

Push the wave as soon as you unlock your waves of fire: Divine Ascent (passive) adds them to your autos, and minions go down much faster.

Cast Divine Judgment (R) on the ally being focused, at the last moment: they become invulnerable, then the area around them damages enemies.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.