Mel vs Twitch

Stay back and poke with Radiant Volley (Q): its projectiles explode in an area up to 950 range, and each hit applies Overwhelm.

Land an auto after each spell: Searing Brilliance (passive) adds three projectiles to it per spell cast, and enough Overwhelm executes the target.

Save Rebuttal (W) for a dangerous projectile: the barrier sends it back to its caster, and you gain a shield and move speed.

Hit your target head-on with Solar Snare (E): only the core of the orb roots, the aura around it just slows and damages.

Cast Golden Eclipse (R) to finish from range: it hits every enemy marked by Overwhelm, wherever they are, harder with each stack.

Get out of the Venom Cask (W) cloud fast: it slows you and adds a Deadly Venom stack every second, which powers up his Contaminate (E).

Ward your brushes and place a Control Ward on his paths: it reveals camouflaged enemies, and Ambush (Q) lets him reach you unseen.

As soon as he comes out of the Ambush (Q) camouflage, focus him with your allies: he's fragile and has no dash to escape.

During Spray and Pray (R), get out of his extended range until the effect ends: his bolts pierce every enemy, so hiding behind an ally won't protect you.