Nami vs Zyra

Cast Aqua Prison (Q) on a slowed or immobile target, or where they're heading: the bubble lands in an area and stuns every enemy on impact.

Cast Tidecaller's Blessing (E) on your ADC just before they trade: their next autos and abilities slow and deal bonus magic damage.

Cast Ebb and Flow (W) so it bounces from one champion to another: it heals each ally, damages each enemy, and only hits the same champion once.

Cast Tidal Wave (R) to engage or to break an enemy engage: enemies hit take a knock-up and a slow, which lasts longer on those farther away.

Get out of the line of Grasping Roots (E): the roots pass through minions and root every enemy hit, then her plants hit the trapped target.

Step on her seeds to destroy them before she grows them: Rampant Growth (W) seeds reveal you for a moment, but leave her no plant.

Take down the plants born from Garden of Thorns (passive), or back off until they die: they take fixed damage, like a ward, and don't live long.

Get out of the Stranglethorns (R) zone as soon as it appears: the vines knock you into the air 2 seconds later, and her plants are empowered inside.

If you can engage, go for Zyra when her plants are far from her: the Thorn Spitter from Deadly Spines (Q) only fires at 575 range.