Senna vs Milio

Attack the souls held by the Mist whenever you can: each soul freed with Absolution (passive) increases your AD, attack range and crit chance.

Fire Piercing Darkness (Q) through an ally or an enemy to hit both: the beam heals your allies, and damages and slows enemies in the line.

Cast Last Embrace (W) on a target that's already slowed or immobilized: after a short delay, they and nearby enemies are rooted.

Cast Curse of the Black Mist (E) to engage or escape with your team: allies who enter it are camouflaged, then fast and unselectable.

Cast Dawning Shadow (R) to save an ally across the map: the beam has unlimited range and shields allies.

Dodge Ultra Mega Fire Kick (Q): it knocks you back, then explodes behind you and slows you.

Back off when Cozy Campfire (W) follows his carry: they gain attack range and restore health over time.

If your team has several CC spells, save one for after Breath of Life (R): it cleanses disabling and immobilizing CC from his nearby allies.

If you can reach him, go for Milio first, especially away from his allies: he has no dash or leap, and without him, his carry loses shields, heals and range.