Senna vs Zyra

Attack the souls held by the Mist whenever you can: each soul freed with Absolution (passive) increases your AD, attack range and crit chance.

Fire Piercing Darkness (Q) through an ally or an enemy to hit both: the beam heals your allies, and damages and slows enemies in the line.

Cast Last Embrace (W) on a target that's already slowed or immobilized: after a short delay, they and nearby enemies are rooted.

Cast Curse of the Black Mist (E) to engage or escape with your team: allies who enter it are camouflaged, then fast and unselectable.

Cast Dawning Shadow (R) to save an ally across the map: the beam has unlimited range and shields allies.

Get out of the line of Grasping Roots (E): the roots pass through minions and root every enemy hit, then her plants hit the trapped target.

Step on her seeds to destroy them before she grows them: Rampant Growth (W) seeds reveal you for a moment, but leave her no plant.

Take down the plants born from Garden of Thorns (passive), or back off until they die: they take fixed damage, like a ward, and don't live long.

Get out of the Stranglethorns (R) zone as soon as it appears: the vines knock you into the air 2 seconds later, and her plants are empowered inside.

If you can engage, go for Zyra when her plants are far from her: the Thorn Spitter from Deadly Spines (Q) only fires at 575 range.