Respect his soldiers' zone: if they're between you and him, he controls that entire area with his autos.

His Shurima Shuffle engages his whole team — spread out so he can't push everyone at once.

Azir is very weak in the early game: punish him before level 6 and before his first item.

Assassins that gap-close directly onto him counter him well because his soldiers don't protect him in melee range.