Viktor vs Karthus

Poke with Hextech Ray (E), fired in the direction you choose: it hits every enemy in its line, and its upgrade adds an aftershock in its wake.

After Siphon Power (Q), land an auto within 4 seconds: it deals bonus magic damage, and the spell's shield covers you during the trade.

Place Gravity Field (W) in your target's path, then fire Hextech Ray (E): the field slows them, and if they stay in it for 1.25 seconds, they're stunned.

Glorious Evolution (passive) upgrades a spell every 100 Hex Fragments: Hextech Ray (E) to poke and clear, Siphon Power (Q) to survive, Gravity Field (W) to slow.

Place Arcane Storm (R) on grouped enemies: it follows the champions it just damaged on its own, and you can recast it to move it.

Stay near your minions or your allies: Lay Waste (Q) deals much more damage when the blast hits only one enemy.

If you can engage, jump on him: Karthus has no dash or leap to escape.

Once he hits level 6, back instead of staying at low health: Requiem (R) hits every enemy champion wherever they are, 3 seconds after he starts channeling.

If you have a shield, a heal or invulnerability, save it for Requiem (R): it hits every enemy champion 3 seconds after he starts channeling.

Once Karthus is dead, move away: Death Defied (passive) keeps him in spirit form for a while, and he can still cast his spells.