Vladimir vs Gragas

After two Transfusion (Q) casts, the next one is empowered for a few seconds: save it for a trade, since it hits harder and heals you based on your missing health.

Last-hit minions with Transfusion (Q) until your items come in: it deals damage before healing you, and costs you nothing.

Charge Tides of Blood (E) for at least 1 second before releasing: the missiles then also slow, and their damage grows with the charge.

Save Sanguine Pool (W) to dodge CC or a burst: for 2 seconds, you're untargetable. It costs you part of your current health.

Cast Hemoplague (R) before your burst: infected enemies take increased damage from all sources, then the blast heals you for each champion hit.

Stay behind your minions: Body Slam (E) stops on the first enemy it meets, minions included.

Get out of the Barrel Roll (Q) area right away: the longer the barrel sits on the ground, the more its explosion hurts and slows.

Step up when Body Slam (E) hits nobody: its cooldown isn't reduced and stays at 14 to 12 seconds.

Spread out from your allies: Explosive Cask (R) knocks every enemy away from the impact, which can split you up or send you toward his team.