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Matchup

Alistar
Alistar
55%
45%

vs

50.0%
Vayne
Vayne
91%
9%
Sustained DPSHeavy AD damageDive threatSplit push

Build vs Vayne

Build adapted to this matchup

Starting items

Health Potion
x2

Core build

Bandlepipes
1vs Hybride
Locket of the Iron Solari
2HP
Thornmail
3vs Hybride

Standard

Boots of Swiftness
4vs Slow
Zeke's Convergence
5Tank

Summoner spells

41456%
4733%

Anti AD

Plated Steelcaps
4vs AD
Knight's Vow
5vs AD
Frozen Heart
vs AD
Randuin's Omen
vs AD

Anti CC

Mercury's Treads
4vs CC

Other options

Zeke's Convergence
Tank
Celestial Opposition
HP
Solstice Sleigh
HP
Protoplasm Harness
Survival
100.0% WR1 games
ResolveResolve
AftershockAftershock
Font of LifeFont of Life
Bone PlatingBone Plating
UnflinchingUnflinching
SorcerySorcery
WaterwalkingWaterwalking
Nimbus CloakNimbus Cloak
Ability HasteHealth ScalingHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
AlistarAlistar
VayneVayne
Favorable
Favorable
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s–
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026