Recommended Build

Playing as Vayne

Tips to maximize your impact

Three hits on the same target
Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.
Tumble between autos
Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.
Pin your target to a wall
Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.
Be patient before your items
Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.
Tumble unseen during your ult
During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

Compare against an opponent

Global strengths and weaknesses

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How to counter and exploit weaknesses

Don't fight with your back to a wall
Don't stand with your back to a wall against her: Condemn (E) knocks you back, and if you hit terrain, you're stunned.
Short, repeated trades
Take short, repeated trades: she's fragile, and on the third consecutive hit on you, Silver Bolts (W) adds true damage based on your max health.
Don't feed her kills during her ult
During Final Hour (R), back off rather than risk your life: each champion she kills after damaging them extends the effect.