Matchup
Heavy AD damageSustained DPSHigh burstHeavy poke
You are stronger late game — farm safe and avoid early trades.
Build vs Miss Fortune
Build adapted to this matchup
Starting items
Core build
Standard
Summoner spells
59%
35%Anti AD
Anti AP
DPS
100.0% WR1 games
Precision
Lethal Tempo
Triumph
Legend: Alacrity
Coup de Grace
Resolve
Conditioning
Overgrowth
Power Spikes
Strength by game phase
Early (0-15)
Mid (15-30)
Late (30+)
Vayne
Miss FortuneNeutral
Neutral
Neutral
Miss Fortune's abilities
Passive, spells and ultimate
Love Tap (P)
Miss Fortune deals bonus physical damage whenever she basic attacks a new target.
Cooldowns
Cooldowns by spell rank
| Level | Q | W | E | R |
|---|---|---|---|---|
| 3 | 7s | 12s | 18s | – |
| 6 | 5s | 12s | 18s | 2m |
| 9 | 3s | 12s | 18s | 2m |
| 11 | 3s | 12s | 18s | 1m50 |
| 16 | 3s | 12s | 16s | 1m40 |
| 18 | 3s | 12s | 14s | 1m40 |
Playing against Miss Fortune
How to counter and exploit weaknesses
1
Interrupt her R: it's a channel and she's immobile. A single CC stops it completely.
2
Don't hide behind low-HP minions: her Q bounces and crits the target behind a dying minion.
3
Engage in melee: MF is weak up close without her R and depends on range.
4
Her W speed breaks as soon as she takes damage — a single auto or ability is enough to cancel it.
Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026