Vayne vs Miss Fortune

Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.

Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.

Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.

Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.

During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

Don't stay behind a low-health minion: if Double Up (Q) kills it, the bounce that hits you always crits.

Hit her regularly, even with a small hit: Strut (W) only grants her passive move speed after a few seconds without taking damage.

If you can engage, get on top of her: Miss Fortune has no dash or leap, only the speed from Strut (W).

If you have CC, save it for Bullet Time (R): she channels in place, and interrupting her cancels the remaining waves.