Recommended Build

Playing as Miss Fortune

Tips to maximize your impact

Double Up off a dying minion
Fire Double Up (Q) at a dying minion in front of a champion: if the shot kills the minion, the bounce onto the champion always crits.
Switch targets
Switch targets often: Love Tap (passive) adds damage on each new target, and lowers the cooldown of Strut (W).
Position with Strut
Activate Strut (W) to get in position before Bullet Time (R): you instantly gain its max move speed bonus, plus attack speed.
R into clumped enemies
Cast Bullet Time (R) on enemies who are CC'd or bunched up in a chokepoint: it's a channeled cone, and each wave can crit.

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Global strengths and weaknesses

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Build, runes and tips against each opponent

How to counter and exploit weaknesses

Don't stand behind low minions
Don't stay behind a low-health minion: if Double Up (Q) kills it, the bounce that hits you always crits.
Cut her speed with a small hit
Hit her regularly, even with a small hit: Strut (W) only grants her passive move speed after a few seconds without taking damage.
Go in if you can
If you can engage, get on top of her: Miss Fortune has no dash or leap, only the speed from Strut (W).
Interrupt her Bullet Time
If you have CC, save it for Bullet Time (R): she channels in place, and interrupting her cancels the remaining waves.