Miss Fortune vs Twitch

Fire Double Up (Q) at a dying minion in front of a champion: if the shot kills the minion, the bounce onto the champion always crits.

Switch targets often: Love Tap (passive) adds damage on each new target, and lowers the cooldown of Strut (W).

Activate Strut (W) to get in position before Bullet Time (R): you instantly gain its max move speed bonus, plus attack speed.

Cast Bullet Time (R) on enemies who are CC'd or bunched up in a chokepoint: it's a channeled cone, and each wave can crit.

Get out of the Venom Cask (W) cloud fast: it slows you and adds a Deadly Venom stack every second, which powers up his Contaminate (E).

Ward your brushes and place a Control Ward on his paths: it reveals camouflaged enemies, and Ambush (Q) lets him reach you unseen.

As soon as he comes out of the Ambush (Q) camouflage, focus him with your allies: he's fragile and has no dash to escape.

During Spray and Pray (R), get out of his extended range until the effect ends: his bolts pierce every enemy, so hiding behind an ally won't protect you.