Miss Fortune vs Seraphine

Fire Double Up (Q) at a dying minion in front of a champion: if the shot kills the minion, the bounce onto the champion always crits.

Switch targets often: Love Tap (passive) adds damage on each new target, and lowers the cooldown of Strut (W).

Activate Strut (W) to get in position before Bullet Time (R): you instantly gain its max move speed bonus, plus attack speed.

Cast Bullet Time (R) on enemies who are CC'd or bunched up in a chokepoint: it's a channeled cone, and each wave can crit.

Dodge Beat Drop (E), especially if you're already slowed: it roots a slowed target and stuns an immobilized one.

Count her basic spells and back off before the third: Stage Presence (passive) casts it twice, whether it damages, slows or shields.

Spread out from your allies against Encore (R): each champion hit extends its range, and a charmed ally near you lets it reach you.

If you can engage, target Seraphine: her kit has no dash to escape.