Matchup
Skill matchup
Build vs Vayne
Build adapted to this matchup
Starting items
Core build
Standard
Summoner spells
94%
2%Anti AD
Anti Heal
Anti AP
Anti Tank
DPS
Other options
Inspiration
First Strike
Cash Back
Biscuit Delivery
Jack Of All Trades
Sorcery
Manaflow Band
Gathering Storm
Power Spikes
Strength by game phase
Miss Fortune
VayneVayne's abilities
Passive, spells and ultimate
Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.
Cooldowns
Cooldowns by spell rank
| Level | Q | W | E | R |
|---|---|---|---|---|
| 3 | 6s | 0s | 20s | – |
| 6 | 4s | 0s | 20s | 1m40 |
| 9 | 2s | 0s | 20s | 1m40 |
| 11 | 2s | 0s | 20s | 1m25 |
| 16 | 2s | 0s | 16s | 1m10 |
| 18 | 2s | 0s | 12s | 1m10 |
Playing against Vayne
How to counter and exploit weaknesses
Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.
Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.
Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.
Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.
Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026