Vayne vs K'Sante

Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.

Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.

Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.

Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.

During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

After two Ntofo Strikes (Q) hit you, back off or dodge the next one: it becomes a shockwave that stuns and pulls.

When he charges Path Maker (W), get out of its line: nothing stops him while he charges, then he rams straight ahead and his dash knocks back and stuns.

Don't fight with your back to a wall when he has All Out (R): if he knocks you into it, you go through, he hits you again and follows, far from your team.

Focus him during All Out (R): he loses max health, bonus armor and bonus magic resist, but heals off his damage, so don't drag it out.