Vayne vs Yone

Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.

Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.

Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.

Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.

During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

Get out of his line after two Mortal Steel (Q) hits: the next one makes him dash forward and knocks the enemies hit into the air.

During Soul Unbound (E), avoid taking hits: when he snaps back, part of all the damage he dealt you is repeated.

If you have ground-targeted CC, place it on the body he left behind: when Soul Unbound (E) ends, he has to return there.

Judge his threat by his crit items more than his level: Way of the Hunter (passive) raises his critical strike chance, so each crit item does more for him.

In teamfights, don't line up with your allies in front of him: Fate Sealed (R) hits every enemy in a line and knocks them into the air toward him.