Vayne vs Sett

Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.

Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.

Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.

Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.

During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

Get out of the center of Haymaker (W): it deals true damage there, and the sides only deal physical damage.

Keep your distance once Knuckle Down (Q) is used: he has no dash, and it's this spell that speeds him toward you.

Don't take a big trade unless you can finish it: Haymaker (W) stores part of the damage he takes as Grit, for a stronger shield and punch.

Don't stay grouped behind your tank: The Show Stopper (R) can slam them onto you, and the damage depends on their bonus health.