Vayne vs Twitch

Hit the same target three times in a row, with autos or spells: on the third hit, Silver Bolts (W) adds true damage based on their max health.

Slip a Tumble (Q) between two autos: you reposition, and your next attack deals bonus damage. Its cooldown drops from 6 to 2 seconds.

Position yourself so that Condemn (E) pushes your target into a wall: if they hit terrain, they're stunned and take more damage.

Play safe while you're missing your first items: Vayne mostly shines later, when Silver Bolts (W) cuts through big health pools.

During Final Hour (R), each Tumble (Q) makes you invisible for a moment and comes back faster: tumble to reposition while the enemy can't target you.

Get out of the Venom Cask (W) cloud fast: it slows you and adds a Deadly Venom stack every second, which powers up his Contaminate (E).

Ward your brushes and place a Control Ward on his paths: it reveals camouflaged enemies, and Ambush (Q) lets him reach you unseen.

As soon as he comes out of the Ambush (Q) camouflage, focus him with your allies: he's fragile and has no dash to escape.

During Spray and Pray (R), get out of his extended range until the effect ends: his bolts pierce every enemy, so hiding behind an ally won't protect you.