Aphelios vs Miss Fortune

With Gravitum as your main weapon, hit your target to slow them, then cast Weapon Abilities (Q): the cannon roots every enemy it has slowed.

Switch to the right weapon with Phase (W) before Moonlight Vigil (R): you then attack each champion hit with your main weapon, and its effect applies.

Before an objective, check Weapon Queue System (E): it shows the weapon Alune will give you next, and an empty weapon goes to the back of the queue.

Don't stay behind a low-health minion: if Double Up (Q) kills it, the bounce that hits you always crits.

Hit her regularly, even with a small hit: Strut (W) only grants her passive move speed after a few seconds without taking damage.

If you can engage, get on top of her: Miss Fortune has no dash or leap, only the speed from Strut (W).

If you have CC, save it for Bullet Time (R): she channels in place, and interrupting her cancels the remaining waves.