Brand vs Locke

Hit the same target with three spells: at 3 stacks, Blaze (passive) becomes unstable and detonates 2 seconds later, dealing heavy damage around it.

Start with Conflagration (E), then Sear (Q) to stun the target while they're ablaze, and finish with Pillar of Flame (W), which deals 25% more damage to them.

Cast Conflagration (E) on a minion that's ablaze near your opponent: when the target is ablaze, the spread range doubles and reaches them.

Cast Pyroclasm (R) when several enemies are close: the torrent bounces up to 5 times, first to champions that are ablaze but not yet at 3 stacks.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.