Recommended Build

Playing as Cassiopeia

Tips to maximize your impact

Poison, then bite
Land Noxious Blast (Q), then chain Twin Fang (E) while the poison lasts: the poisoned target takes extra damage, and you heal.
Kite with your speed
Hit a champion with Noxious Blast (Q) to kite: the spell gives you move speed, and Serpentine Grace (passive) makes every speed bonus more effective.
Ground those who dive you
Place Miasma (W) on those trying to jump on you: inside the clouds, enemies are slowed and can't use movement abilities.
Turn to face your pursuers
Cast Petrifying Gaze (R) toward those chasing you, after a Flash if needed: those facing you are stunned, the others only slowed.

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Global strengths and weaknesses

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Build, runes and tips against each opponent

How to counter and exploit weaknesses

Dodge her poison
Dodge Noxious Blast (Q): without poison on you, Twin Fang (E) deals much less damage and doesn't heal her.
Walk around her clouds
Walk around the Miasma (W) clouds: inside, you're slowed and can't use dashes or jumps.
Turn your back on her R
Turn your back to her when she casts Petrifying Gaze (R): facing her, you're stunned; facing away, you're only slowed.