Gragas vs Mordekaiser

Let Barrel Roll (Q) charge before detonating it: damage and slow grow the longer it sits on the ground, and if you don't recast it, it explodes on its own.

Drink Drunken Rage (W) before engaging: drinking takes 1 second, then you take less damage and your next auto hits every nearby enemy.

Engage with Body Slam (E) through a path without minions: you stop on the first enemy you meet, and hitting reduces its cooldown.

After Body Slam (E), cast Explosive Cask (R) behind your target: the blast knocks enemies away from the impact, sending them toward your team.

Stay near your minions against Obliterate (Q): its damage increases when it hits only one enemy.

Dodge Death's Grasp (E): it pulls you toward him, into his other spells, and it has a 16 to 8 second cooldown.

If you have range, kite him: Mordekaiser has no dash, and only Death's Grasp (E), which pulls you in, closes the distance.

In Realm of Death (R), save your mobility spells to escape him rather than for the duel: he steals part of your stats, and keeps them if he kills you.