Graves vs Zyra

Position with no minion between you and your target: each New Destiny (passive) auto fires 4 bullets that can't pass through units.

Cast Smoke Screen (W) on their carries: inside the smoke, they're slowed and can't see anything outside it for 4 seconds.

Fire Collateral Damage (R) with your back to the danger: the shot knocks you backward, enough to reposition while dealing damage.

Cast Quickdraw (E) often during your clear: it reloads a shell, gives armor and magic resist, and each bullet that hits lowers its cooldown.

Get out of the line of Grasping Roots (E): the roots pass through minions and root every enemy hit, then her plants hit the trapped target.

Step on her seeds to destroy them before she grows them: Rampant Growth (W) seeds reveal you for a moment, but leave her no plant.

Take down the plants born from Garden of Thorns (passive), or back off until they die: they take fixed damage, like a ward, and don't live long.

Get out of the Stranglethorns (R) zone as soon as it appears: the vines knock you into the air 2 seconds later, and her plants are empowered inside.

If you can engage, go for Zyra when her plants are far from her: the Thorn Spitter from Deadly Spines (Q) only fires at 575 range.