Matchup

Sustained DPSHeavy AD damageDive threatSplit push

Build vs Vayne

Build adapted to this matchup

Starting items

Health Potion
x2

Core build

Malignance
1Mage
Moonstone Renewer
2HP
Echoes of Helia
3HP

Standard

Ionian Boots of Lucidity
4CDR
Dream Maker
5HP

Summoner spells

4788%
4148%

Anti CC

Mercury's Treads
4vs CC

DPS

Imperial Mandate
Mage

Other options

Dream Maker
HP
Redemption
Zaz'Zak's Realmspike
HP
Ardent Censer
Shurelya's Battlesong
Mikael's Blessing
HP
Celestial Opposition
HP
Dawncore
100.0% WR1 games
SorcerySorcery
Summon AerySummon Aery
Manaflow BandManaflow Band
TranscendenceTranscendence
Gathering StormGathering Storm
ResolveResolve
RevitalizeRevitalize
Font of LifeFont of Life
Ability HasteAdaptive ForceHealth

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
KarmaKarma
VayneVayne
Favorable
Favorable
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026