Karthus vs Miss Fortune

Not enough games

Heavy AD damageHigh burstSustained DPSHeavy poke

Build vs Miss Fortune

The champion's reference build, for lack of enough games in this matchup

Starting items

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Core build

1—

2—

3—

Standard

4Magic pen

5—

Anti CC

4vs CC

Other options

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Strength by game phase

Passive, spells and ultimate

Love Tap (P)

Miss Fortune deals bonus physical damage whenever she basic attacks a new target.

Cooldowns by spell rank

Level	Q	W	E	R
3	7s	12s	18s	–
6	5s	12s	18s	2m
9	3s	12s	18s	2m
11	3s	12s	18s	1m50
16	3s	12s	16s	1m40
18	3s	12s	14s	1m40

Tips to maximize your impact

Aim for isolated champions
Aim Lay Waste (Q) at a champion away from their minions: if the blast hits only one enemy, it deals much more damage.
Wall before your combo
Place Wall of Pain (W) in their path before your combo: anyone who crosses it is slowed and loses magic resist.
Keep playing after you die
After you die, keep casting your spells: Death Defied (passive) keeps you in spirit form for a while, and you can still cast Lay Waste (Q) and Requiem (R).
Requiem for the finish
Save Requiem (R) to finish off wounded enemies, often right after a teamfight: it hits every enemy champion wherever they are, after a 3-second channel.

How to counter and exploit weaknesses

Don't stand behind low minions
Don't stay behind a low-health minion: if Double Up (Q) kills it, the bounce that hits you always crits.
Cut her speed with a small hit
Hit her regularly, even with a small hit: Strut (W) only grants her passive move speed after a few seconds without taking damage.
Go in if you can
If you can engage, get on top of her: Miss Fortune has no dash or leap, only the speed from Strut (W).
Interrupt her Bullet Time
If you have CC, save it for Bullet Time (R): she channels in place, and interrupting her cancels the remaining waves.

Patch 16.21.1