Matchup
Build vs Vayne
Build adapted to this matchup
Starting items
Core build
Standard
Summoner spells
98%
1%Anti AD
Anti CC
Anti Tank
DPS
Inspiration
First Strike
Cash Back
Triple Tonic
Cosmic Insight
Domination
Treasure Hunter
Sudden Impact
Power Spikes
Strength by game phase
Khazix
VayneVayne's abilities
Passive, spells and ultimate
Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.
Cooldowns
Cooldowns by spell rank
| Level | Q | W | E | R |
|---|---|---|---|---|
| 3 | 6s | 0s | 20s | – |
| 6 | 4s | 0s | 20s | 1m40 |
| 9 | 2s | 0s | 20s | 1m40 |
| 11 | 2s | 0s | 20s | 1m25 |
| 16 | 2s | 0s | 16s | 1m10 |
| 18 | 2s | 0s | 12s | 1m10 |
Playing against Vayne
How to counter and exploit weaknesses
Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.
Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.
Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.
Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.
Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026