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Matchup

Lissandra
Lissandra
20%
80%

vs

50.0%
Vayne
Vayne
91%
9%
Sustained DPSHeavy AD damageDive threatSplit push

Build vs Vayne

Build adapted to this matchup

Starting items

Doran's Ring
Health Potion
x2

Core build

Malignance
1Mage
Hextech Rocketbelt
2Mage tank
Zhonya's Hourglass
3vs AD

Standard

Sorcerer's Shoes
4Magic pen
Shadowflame
5vs Tank

Summoner spells

41274%
41426%

Anti AP

Mercury's Treads
4vs CC
Banshee's Veil
5vs AP

Anti Tank

Shadowflame
5vs Tank
Stormsurge
vs Tank
Void Staff
vs Tank

DPS

Rabadon's Deathcap
Mage
Luden's Echo
Mage
Blackfire Torch
Mage

Other options

Dark Seal
Oblivion Orb
100.0% WR6 games
DominationDomination
ElectrocuteElectrocute
Cheap ShotCheap Shot
Grisly MementosGrisly Mementos
Ultimate HunterUltimate Hunter
SorcerySorcery
TranscendenceTranscendence
Manaflow BandManaflow Band
Adaptive ForceAdaptive ForceHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
LissandraLissandra
VayneVayne
Favorable
Favorable
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s–
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026