Miss Fortune vs Kog'Maw

Fire Double Up (Q) at a dying minion in front of a champion: if the shot kills the minion, the bounce onto the champion always crits.

Switch targets often: Love Tap (passive) adds damage on each new target, and lowers the cooldown of Strut (W).

Activate Strut (W) to get in position before Bullet Time (R): you instantly gain its max move speed bonus, plus attack speed.

Cast Bullet Time (R) on enemies who are CC'd or bunched up in a chokepoint: it's a channeled cone, and each wave can crit.

Engage when Bio-Arcane Barrage (W) ends: his attack range drops back to 500, and the spell has a 17-second cooldown.

If you can engage, go for him: with no dash or leap, Kog'Maw can only back off on foot, and Void Ooze (E) is his only slow.

Below 40% health, get out of range of Living Artillery (R): each shot then deals its max damage to you, and it reaches very far.

When he dies, move away from him: Icathian Surprise (passive) makes him explode 4 seconds later, dealing true damage to nearby enemies.