Miss Fortune vs Ziggs

Fire Double Up (Q) at a dying minion in front of a champion: if the shot kills the minion, the bounce onto the champion always crits.

Switch targets often: Love Tap (passive) adds damage on each new target, and lowers the cooldown of Strut (W).

Activate Strut (W) to get in position before Bullet Time (R): you instantly gain its max move speed bonus, plus attack speed.

Cast Bullet Time (R) on enemies who are CC'd or bunched up in a chokepoint: it's a channeled cone, and each wave can crit.

Walk around Hexplosive Minefield (E): each mine explodes on contact and slows you, which helps him land his other spells.

If you can engage, go in right after Satchel Charge (W): it's his only way to get away, on a 20 to 12 second cooldown.

If Mega Inferno Bomb (R) lands on you, at least get out of the center: the center of the blast deals more damage than the edge.