Matchup

Nilah
Nilah
67%
33%

vs

48.4%

over 733 games

Vayne
Vayne
91%
9%
Sustained DPSHeavy AD damageDive threatSplit push

Skill matchup

You are stronger late game — farm safe and avoid early trades.

Build vs Vayne

Build adapted to this matchup

Starting items

Doran's Blade
Health Potion

Core build

The Collector
1vs Tank
Immortal Shieldbow
2DPS
Lord Dominik's Regards
3vs Tank

Standard

Boots of Swiftness
4vs Slow
Infinity Edge
5DPS

Summoner spells

42177%
3411%

Anti AD

Plated Steelcaps
4vs AD
Death's Dance
5vs AD
Guardian Angel
vs AD
Randuin's Omen
vs AD
Frozen Heart
vs AD

Anti Heal

Mortal Reminder
6vs Hybride

Anti AP

Mercury's Treads
4vs CC
Mercurial Scimitar
5vs AP
Spirit Visage
vs AP
Maw of Malmortius
vs AP

Anti Tank

Serpent's Fang
5vs Tank
Hubris
vs Tank
Voltaic Cyclosword
vs Tank
Edge of Night
vs Tank

DPS

Infinity Edge
DPS
Yun Tal Wildarrows
DPS
Fiendhunter Bolts
DPS
Bloodthirster
DPS
Navori Flickerblade
DPS
Phantom Dancer
DPS
Endless Hunger
DPS
Essence Reaver
DPS
Stormrazor
DPS
Blade of The Ruined King
DPS
Hexoptics C44
DPS
100.0% WR6 games
PrecisionPrecision
ConquerorConqueror
TriumphTriumph
Legend: AlacrityLegend: Alacrity
Last StandLast Stand
InspirationInspiration
Cash BackCash Back
Cosmic InsightCosmic Insight
Attack SpeedAdaptive ForceHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
NilahNilah
VayneVayne
Aggressive
Neutral
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026