Recommended Build

Playing as Ryze

Tips to maximize your impact

Flux, then Overload
Cast Spell Flux (E) on your target or a nearby minion, then Overload (Q): the Flux spreads to nearby enemies, and the bolt bounces from one to the next.
Root a target with Flux
Cast Rune Prison (W) on a target marked by Spell Flux (E): they're rooted instead of slowed.
Alternate your spells
Alternate your spells in teamfights: Rune Prison (W) and Spell Flux (E) reset the cooldown of Overload (Q).
Open a portal for your team
Cast Realm Warp (R) to rotate to an objective or a flank: after a few seconds, all allies near you are teleported.

Compare against an opponent

Global strengths and weaknesses

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Build, runes and tips against each opponent

How to counter and exploit weaknesses

Back off when he marks you
Back off when Spell Flux (E) marks you: marked, Rune Prison (W) roots you instead of slowing you, and Overload (Q) hits you harder.
Target him when he comes close
If you can engage, target him when he comes close for his combo: he has no dash to get away.
Interrupt his portal
If you have CC, use it on Ryze while Realm Warp (R) is charging: it cancels the portal.