Ryze vs Akali

Power Spikes

Strength by game phase

Passive, spells and ultimate

Assassin's Mark (P)

Dealing spell damage to a champion creates a ring of energy around them. Exiting that ring empowers Akali's next Attack with bonus range and damage.

Cooldowns by spell rank

Level	Q	W	E	R
3	1.5s	20s	16s	–
6	1.5s	20s	16s	2m
9	1.5s	19s	16s	2m
11	1.5s	18s	16s	1m30
16	1.5s	16s	13s	1m
18	1.5s	16s	10s	1m

Tips to maximize your impact

Flux, then Overload
Cast Spell Flux (E) on your target or a nearby minion, then Overload (Q): the Flux spreads to nearby enemies, and the bolt bounces from one to the next.
Root a target with Flux
Cast Rune Prison (W) on a target marked by Spell Flux (E): they're rooted instead of slowed.
Alternate your spells
Alternate your spells in teamfights: Rune Prison (W) and Spell Flux (E) reset the cooldown of Overload (Q).
Open a portal for your team
Cast Realm Warp (R) to rotate to an objective or a flank: after a few seconds, all allies near you are teleported.

How to counter and exploit weaknesses

Trade after her smoke
Take a trade once Twilight Shroud (W) is used: she can't vanish again until its 20 to 16 second cooldown is over.
Play hard before she hits 6
Play hard before she hits level 6: without Perfect Execution (R), her only spell to get back on you is Shuriken Flip (E), on a 16 to 10 second cooldown.
Fire into her smoke
If you have AoE spells or skillshots, throw them into the Twilight Shroud (W) smoke: they hit her even while she's invisible, whereas targeted spells can't be cast on her.
Punish her when she's low on energy
Take a trade when she has just cast Five Point Strike (Q) several times: each cast costs 110 to 70 energy depending on rank, from a base pool of 200.
Hit her between her two dashes
Hit her right after the first dash of Perfect Execution (R): she has to wait a moment before she can cast the second.