Sion vs Locke

Last-hit minions and monsters for Soul Furnace (W): each kill permanently gives you max health, more on champions, large minions and large monsters.

Slow your target with Roar of the Slayer (E) before charging Decimating Smash (Q): they're less likely to get out of the area.

Charge Decimating Smash (Q) for at least 1 second: below that, the hit only slows, and beyond it, the knock-up and stun last longer the more you charge.

After you die, hit the nearest champion: during Glory in Death (passive), your autos are much faster, heal you and deal damage based on their max health.

Cast Unstoppable Onslaught (R) from far away to engage or roam: unstoppable for 8 seconds, you stun longer and hit harder after a long charge.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.