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Matchup

Skarner
Skarner
58%
42%

vs

50.0%
Vayne
Vayne
91%
9%
Sustained DPSHeavy AD damageDive threatSplit push

Build vs Vayne

Build adapted to this matchup

Starting items

Mosstomper Seedling

Core build

Protoplasm Harness
1Survival
Bandlepipes
2vs Hybride
Randuin's Omen
3vs AD

Standard

Boots of Swiftness
4vs Slow
Heartsteel
5Survival

Summoner spells

411100%

Anti AD

Plated Steelcaps
4vs AD
Thornmail
5vs Hybride
Sunfire Aegis
vs AD
Frozen Heart
vs AD
Unending Despair
vs AD

Anti AP

Mercury's Treads
4vs CC
Jak'Sho, The Protean
5vs Hybride
Spirit Visage
vs AP

Other options

Heartsteel
Survival
Overlord's Bloodmail
HP
100.0% WR1 games
ResolveResolve
Grasp of the UndyingGrasp of the Undying
Shield BashShield Bash
ConditioningConditioning
OvergrowthOvergrowth
InspirationInspiration
Magical FootwearMagical Footwear
Cosmic InsightCosmic Insight
Ability HasteHealth ScalingHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
SkarnerSkarner
VayneVayne
Favorable
Favorable
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s–
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026