Thresh vs Karma

Open with Flay (E) before Death Sentence (Q): the slow makes the hook much easier to land.

In lane, space out your autos: Flay (E) charges them passively, and the longer you wait between two autos, the more damage they deal.

Don't recast Death Sentence (Q) on reflex: the target is already being pulled toward you, and jumping on them often exposes you for nothing.

Throw Dark Passage (W) toward an ally in trouble before they need it: they can click it to come back to you, with a shield.

Place The Box (R) right after a successful hook: to escape, the target has to break a wall, and the first wall broken slows them and deals full damage.

Play carefully at the very start of lane: Mantra (R) is available from level 1, so Karma already has an empowered spell.

Move away as soon as Focused Resolve (W) tethers you: if the tether holds to the end, you take damage again and get rooted.

Quickly leave the ring of fire left by Inner Flame (Q) empowered by Mantra (R): it slows and deals extra damage.

If you can reach her, focus her in teamfights: Mantra (R) then Inspire (E) gives a shield and move speed to every ally grouped around her target.