Thresh vs Nautilus

Open with Flay (E) before Death Sentence (Q): the slow makes the hook much easier to land.

In lane, space out your autos: Flay (E) charges them passively, and the longer you wait between two autos, the more damage they deal.

Don't recast Death Sentence (Q) on reflex: the target is already being pulled toward you, and jumping on them often exposes you for nothing.

Throw Dark Passage (W) toward an ally in trouble before they need it: they can click it to come back to you, with a shield.

Place The Box (R) right after a successful hook: to escape, the target has to break a wall, and the first wall broken slows them and deals full damage.

Once he hits level 2, stay behind your minions: the Dredge Line (Q) anchor hooks the first enemy hit, then the Staggering Blow (passive) auto keeps you in place.

When he casts Riptide (E) near you, stay put until it ends: its three explosions spread out around him, and running too early makes you take the next ones and their slow.

When Dredge Line (Q) misses you, keep your distance: it's his only spell to reach you, on a 14 to 10 second cooldown.

When he aims Depth Charge (R) at an ally, don't stand between them: the shockwave chases its target, and every enemy in its path takes a knock-up.