Thresh vs Locke

Open with Flay (E) before Death Sentence (Q): the slow makes the hook much easier to land.

In lane, space out your autos: Flay (E) charges them passively, and the longer you wait between two autos, the more damage they deal.

Don't recast Death Sentence (Q) on reflex: the target is already being pulled toward you, and jumping on them often exposes you for nothing.

Throw Dark Passage (W) toward an ally in trouble before they need it: they can click it to come back to you, with a shield.

Place The Box (R) right after a successful hook: to escape, the target has to break a wall, and the first wall broken slows them and deals full damage.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.