Thresh vs Soraka

Open with Flay (E) before Death Sentence (Q): the slow makes the hook much easier to land.

In lane, space out your autos: Flay (E) charges them passively, and the longer you wait between two autos, the more damage they deal.

Don't recast Death Sentence (Q) on reflex: the target is already being pulled toward you, and jumping on them often exposes you for nothing.

Throw Dark Passage (W) toward an ally in trouble before they need it: they can click it to come back to you, with a shield.

Place The Box (R) right after a successful hook: to escape, the target has to break a wall, and the first wall broken slows them and deals full damage.

Dodge Starcall (Q): if it hits a champion, Soraka heals and speeds up, and can pass that heal on to an ally.

Get out of Equinox (E) fast: you're silenced inside, and rooted if you're still there when the zone disappears.

If you can reach her, focus Soraka rather than the ally she heals: she has no dash, and each Astral Infusion (W) costs her health.

Finish your targets in a single burst: Wish (R) heals them wherever they are, and more below 40% health.