Matchup
You are stronger late game — farm safe and avoid early trades.
Build vs Seraphine
Build adapted to this matchup
Starting items
Core build
Standard
Summoner spells
86%
14%Anti AD
Anti AP
DPS
Precision
Lethal Tempo
Triumph
Legend: Alacrity
Coup de Grace
Resolve
Conditioning
Overgrowth
Power Spikes
Strength by game phase
Vayne
SeraphineSeraphine's abilities
Passive, spells and ultimate
Every third basic spell will cast twice from Seraphine. Additionally, casting spells near allies grants her bonus magic damage and range on her next basic attack.
Cooldowns
Cooldowns by spell rank
| Level | Q | W | E | R |
|---|---|---|---|---|
| 3 | 8s | 22s | 11s | – |
| 6 | 7s | 22s | 11s | 2m40 |
| 9 | 6s | 22s | 11s | 2m40 |
| 11 | 6s | 22s | 11s | 2m20 |
| 16 | 6s | 22s | 10s | 2m |
| 18 | 6s | 22s | 9s | 2m |
Playing against Seraphine
How to counter and exploit weaknesses
Spread out to avoid the R chaining — if an ally is hit, move away from them.
Her E alone only slows: it's dangerous ONLY if you're already slowed or CC'd.
Seraphine is immobile and squishy — assassins and flanks punish her well.
Her passive doubles every 3rd ability: if she has the visible halo, prepare for a double cast.
Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026