Vex vs Locke

When Doom 'n Gloom (passive) is ready, save Personal Space (W) for the enemy who jumps on you: the shockwave fears them and interrupts their dash, and you gain a shield.

When an enemy dashes near you, Doom 'n Gloom (passive) marks them: hit them with Mistral Bolt (Q) for bonus damage, and your empowerment comes back sooner.

After the Shadow Surge (R) dash, follow up with Personal Space (W): the shield protects you on arrival, and the shockwave fears if Doom 'n Gloom (passive) is ready.

If the champion marked by Shadow Surge (R) dies shortly after being hit by it, its cooldown is reset for a moment: recast it right away at another target.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.