Matchup

Sustained DPSHeavy AD damageDive threatSplit push

Build vs Vayne

Build adapted to this matchup

Starting items

Doran's Ring
Health Potion
x2

Core build

Luden's Echo
1Mage
Shadowflame
2vs Tank
Stormsurge
3vs Tank

Standard

Sorcerer's Shoes
4Magic pen
Zhonya's Hourglass
5vs AD

Summoner spells

41457%
41243%

Anti AD

Plated Steelcaps
4vs AD
Zhonya's Hourglass
5vs AD

Anti CC

Mercury's Treads
4vs CC

Anti Tank

Void Staff
5vs Tank

DPS

Rabadon's Deathcap
Mage

Other options

Dark Seal
100.0% WR2 games
DominationDomination
ElectrocuteElectrocute
Taste of BloodTaste of Blood
Grisly MementosGrisly Mementos
Ultimate HunterUltimate Hunter
SorcerySorcery
TranscendenceTranscendence
Manaflow BandManaflow Band
Attack SpeedAdaptive ForceHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
VexVex
VayneVayne
Favorable
Favorable
Passive

Vayne's abilities

Passive, spells and ultimate

Night Hunter (P)

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Cooldowns

Cooldowns by spell rank

LevelQWER
36s0s20s
64s0s20s1m40
92s0s20s1m40
112s0s20s1m25
162s0s16s1m10
182s0s12s1m10

Playing against Vayne

How to counter and exploit weaknesses

1

Punish her aggressively in the early game (levels 1-5): Vayne has short range (550) and no waveclear, she's very vulnerable.

2

Buy Plated Steelcaps — they reduce her auto-attack damage which is her only source of DPS.

3

Avoid fights near walls: her E (Condemn) stuns against walls for a long duration.

4

Control Wards and Oracle Lens reveal Vayne during her invisibility (R+Q) — place them in teamfights to target her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026