Vladimir vs Cho'Gath

After two Transfusion (Q) casts, the next one is empowered for a few seconds: save it for a trade, since it hits harder and heals you based on your missing health.

Last-hit minions with Transfusion (Q) until your items come in: it deals damage before healing you, and costs you nothing.

Charge Tides of Blood (E) for at least 1 second before releasing: the missiles then also slow, and their damage grows with the charge.

Save Sanguine Pool (W) to dodge CC or a burst: for 2 seconds, you're untargetable. It costs you part of your current health.

Cast Hemoplague (R) before your burst: infected enemies take increased damage from all sources, then the blast heals you for each champion hit.

Keep moving against him: Rupture (Q) strikes an area on the ground, and an enemy standing still takes a knock-up, damage and a slow.

Punish him when he goes for last hits: Carnivore (passive) restores health and mana for each unit he kills, and he lasts a long time in lane if you let him farm.

If you have range, keep your distance: his kit has no dash, only the slows from Rupture (Q) and Vorpal Spikes (E).

Don't stay in melee range at low health when Feast (R) is up: its true damage ignores your resistances, even if you're a tank.