Annie vs Locke

Last-hit minions with Disintegrate (Q): if the target dies, the spell refunds its mana and its cooldown is halved.

Stack Pyromania (passive) with Molten Shield (E): after 4 spells, your next offensive spell stuns, without you having to step forward.

Cast Summon: Tibbers (R) on a group when Pyromania (passive) is ready, after a Flash if needed: the summon then stuns the enemies hit.

Recast Summon: Tibbers (R) to direct Tibbers: he burns nearby enemies, and each stun you land on a champion makes him enraged and faster.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.