Cho'Gath vs Locke

Aim Rupture (Q) where your opponent is going, not where they are: the area knocks them into the air and slows them.

Follow a successful Rupture (Q) with Feral Scream (W): the silence stops them from casting spells, dashes included.

Cast Vorpal Spikes (E) before a trade: your next 3 autos launch spikes that slow enemies in front of you and deal damage based on their max health.

Finish with Feast (R) as soon as it's up: each kill gives you permanent max health, but minions and non-epic monsters only give a limited amount.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.