Ezreal vs Seraphine

Land Mystic Shot (Q) as often as you can: each hit lowers all your cooldowns and adds a Rising Spell Force (passive) stack.

Detonate Essence Flux (W) with a spell rather than an auto: the orb deals its damage either way, but a spell refunds its mana cost plus a bonus.

Save Arcane Shift (E) to escape unless the kill is certain: it's your only way to reposition, on a 26 to 14 second cooldown.

Cast Trueshot Barrage (R) across the map to finish a fleeing target: it hits everything in its line, but deals less to minions and non-epic monsters.

Dodge Beat Drop (E), especially if you're already slowed: it roots a slowed target and stuns an immobilized one.

Count her basic spells and back off before the third: Stage Presence (passive) casts it twice, whether it damages, slows or shields.

Spread out from your allies against Encore (R): each champion hit extends its range, and a charmed ally near you lets it reach you.

If you can engage, target Seraphine: her kit has no dash to escape.