Ezreal vs Twitch

Land Mystic Shot (Q) as often as you can: each hit lowers all your cooldowns and adds a Rising Spell Force (passive) stack.

Detonate Essence Flux (W) with a spell rather than an auto: the orb deals its damage either way, but a spell refunds its mana cost plus a bonus.

Save Arcane Shift (E) to escape unless the kill is certain: it's your only way to reposition, on a 26 to 14 second cooldown.

Cast Trueshot Barrage (R) across the map to finish a fleeing target: it hits everything in its line, but deals less to minions and non-epic monsters.

Get out of the Venom Cask (W) cloud fast: it slows you and adds a Deadly Venom stack every second, which powers up his Contaminate (E).

Ward your brushes and place a Control Ward on his paths: it reveals camouflaged enemies, and Ambush (Q) lets him reach you unseen.

As soon as he comes out of the Ambush (Q) camouflage, focus him with your allies: he's fragile and has no dash to escape.

During Spray and Pray (R), get out of his extended range until the effect ends: his bolts pierce every enemy, so hiding behind an ally won't protect you.